Can vitamin D halt growth of triple-negative breast cancer? (Article by Natural News)

Can vitamin D halt growth of triple-negative breast cancer?

by David Gutierrez, staff writer

Vitamin D supplementation may be able to slow or even halt the progression of the most dangerous variety of breast cancer, according to a study conducted by researchers from Saint Louis University and IRBLleida, Spain, and published in The Journal of Cell Biology. In addition, the researcher’s isolated biomarkers that could help physicians identify women that could benefit from vitamin D treatment.

The researchers came to this discovery by identifying, for the first time, one of the molecular pathways that leads to the variety of breast cancer known as triple-negative. This cancer is more likely to affect younger women, and is most resistant to treatment.

Scientists have known for some time that a malfunction of a tumor-suppressing gene known as BRCA1 can lead to the development of breast cancer. This gene is part of the cellular defense system by which the body ensures that any damaged DNA is not passed on to new cells, using mechanisms such as screening DNA for errors and sending cells carrying damaged DNA into hibernation or even programmed cell death. This is an important cancer-preventive role, because an accumulation of DNA damage can lead a cell to the out-of-control replication associated with cancerous tumors.

BRCA1 plays a role in screening DNA and repairing double-strand breaks, a particularly dangerous form of damage. It also plays a role in verifying that DNA has been replicated and transferred properly to new cells. When BRCA1 fails, it may lead to the development of breast cancer, and often the particular variety that is negative for receptors of two hormones and a protein: estrogen, progesterone and HER2. Because such tumors are not dependent on these external factors for growth, they are harder to "starve" and kill.

The vitamin D link

Yet not all BRCA1-mutated cells turn into breast tumors. In a recent study, researchers determined that in the presence of another DNA repair factor known as 53BP1, BRCA1-deficient cells can still survive and reproduce in health. As 53BP1 levels decrease, the development of triple-negative tumors becomes more likely.

In the new study, the researchers found that the loss of BRCA1 begins a chain of events in which a protein-degrading chemical is produced that starts to break down 53BP1.

"It's a new pathway that explains how breast cancer cells lose 53BP1," lead researcher Susana Gonzalo said.

Significantly, prior research has shown that in the presence of vitamin D, this chemical is less effective at degrading 53BP1. In the new study, they found that when BRCA1-deficient tumor cells were exposed to vitamin D, 53BP1 levels rose and proliferation slowed.

This is a particularly important discovery because triple-negative breast cancers tend to be resistant to many of the most advanced cancer drugs, while the therapy that they are more likely to respond to - chemotherapy - carries potentially severe side effects.

The researchers now believe that even in people who have already developed a drug-resistant, triple-negative cancer, vitamin D supplementation may actually render the tumors sensitive to drugs.

Sources:

http://www.sciencedaily.com/releases/2013/01/130122142911.htm
http://phys.org

---

All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing LLC takes sole responsibility for all content. Truth Publishing sells no hard products and earns no money from the recommendation of products. NaturalNews.com is presented for educational and commentary purposes only and should not be construed as professional advice from any licensed practitioner. Truth Publishing assumes no responsibility for the use or misuse of this material. For the full terms of usage of this material, visit www.NaturalNews.com/terms.shtml

ZYTO EVOX demonstration Doctor shows the importance of perception reframing

EVOX by Zyto changes everything because it affects emotions which affect every aspect of healing.

Kelley Metabolic Center and Testing Cancer Center (http://www.kelleymetabolic.com/) has implemented a new ZYTO biocommunication program that enables extensive health related information about each patient to be gathered through a direct link between the patient and the computer. This information is then used to by Clinic as part of a holistic approach to improving the health and wellness.

The scan is complementary for new clients, and takes less than five minutes to conduct. Using ZYTO technology, Kelley Metabolic center and Testing Cancer Center can identify a biological preference for nutrition, therapies and treatments as part of a process of creating a personalized and unique wellness program for each individual client.

"One size does not fit all when it comes to health and wellness. Using ZYTO we are able to approach wellness on an individual basis, creating a custom plan for each unique patient," said Dr. Vaugn.  "The results have been impressive because this approach takes into account the body's own biological preference as part of our development of a holistic health plan,"

ChemoBrainFog Reversal Naturally

Scientists have long been aware of the wide array of health benefits from the Indian spice turmeric, which is a source of the active phytochemical curcumin. Until now, curcumin has been known to have poor bioavailability, requiring high doses to promote health. BCM-95 delivers significantly more pharmacologically bioactive curcumin into the blood than other curcumin sources. This new delivery system allows for a variety of health benefits.

How is this possible? Traditional 95% extract focuses strictly on one part of the Turmeric rhizome. This bioactive substance of Turmeric (Curcuma Longa) contains “Curcuminoids” and Curcumin is the most important molecule. Research has shown its tremendous health benefit. Even though Curcumin is the most important molecule, the bioavailability of the regular Turmeric 95% extracts sold on the market is not very good in terms of uptake or sustainability in the blood stream. There are other essential components present in Turmeric Rhizome which have been neglected during the traditional method of manufacturing of Turmeric 95% Extract. BCM-95 represents the natural spectrum of turmeric rhizome. It is 100 percent natural and has been proven to provide optimal bioavailability for synergistic effect. This new method of manufacture offers tremendous value in terms of bioavailability.

Antioxidants have received increased attention, and it’s important to know what nutrients are antioxidants and information about them. One such nutrient is Curcumin. Curcumin is a natural extract from the spice turmeric. Turmeric is derived from the plant Curcuma Longa, a member of the ginger family.

Curcumin is employed mostly as an antioxidant; though it was traditionally used to promote stomach and joint comfort. The immune-balancing activity of curcumin has been demonstrated through multiple mechanisms to support normal COX-2 and NF-KappaB levels in the body.

The neuroprotective properties of curcumin are among the most studied. Curcumin has been designated as a strong candidate for the promotion of neurological health and cognitive function. Curcumin can cross the blood-brain barrier and support the normal uptake of amyloid-beta in the brain. This supports the brain's memory and learning abilities as we age. Another neuroprotective property of curcumin is its ability to promote normal levels of glutathione, superoxide dismutase and catalase in the brain. This can help to maintain the health of neurological tissues.

Curcumin supports the normal production of Phase II liver detoxification enzymes including glutathione synthase, heme-oxygenase and catalase. The liver plays several roles in detoxification: it filters the blood to remove large toxins, synthesizes and secretes bile full of cholesterol and other fat-soluble toxins, and enzymatically disassembles unwanted chemicals. This enzymatic process usually occurs in two steps referred to as phase I and phase II. They promote the body’s natural enzyme antioxidant defense systems and function as a powerful indirect antioxidant. These enzymes promote the body’s normal metabolism of harmful chemicals such as heavy metals, toxins and pollutants into less reactive molecules. Curcumin has also been shown to promote normal hepatic tissue repair.Broccoli Seed Extract (6% Sulphoraphane Glucosinolates): 167 mg The health benefits and protective properties of broccoli and other cruciferous vegetables have been well documented over the past 25 years. Broccoli seed extract is a powerful source of sulphoraphane glucosinolates. Sulforaphanes support the normal production of Phase II liver detoxification enzymes including glutathione synthase, heme-oxygenase and catalase. Sulforaphanes promote the body’s natural enzyme antioxidant defense systems and function as a powerful indirect antioxidant. Sulphoraphanes work to support gene transcription, which is the process by which genetic information is copied from DNA to RNA, resulting in a specific protein formation. Conclusively, sulphoraphanes work to support the body’s natural defense systems and to maintain elevated levels of glutathione.

Glutathione is the master antioxidant of the body. It is an important chemical that acts as a powerful antioxidant to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals. It also acts to recycle vitamin C and E, which also reduce free radicals. Since glutathione cannot be absorbed intact orally due to gastrointestinal degradation, sulphoraphane supplementation may be the most effective way to increase endogenous glutathione concentration.Selenium (Selenomethionine): 100 mcg Selenium is a required cofactor for selenoproteins such as glutathione peroxidase. Selenomethionine is incorporated directly into proteins because selenomethionine cannot be distinguished from methionine during the translation of mRNA into protein. This serves as a storage form of selenium and is liberated upon protein catabolism. Selenium accumulates in the prostate, promoting the health of the prostate. Selenium supports immune function by promoting normal growth and development of T helper cells.